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Design and Synthesis of 2‘,3‘-Dideoxy- 2‘,3‘-didehydro-β- l -cytidine (β- l -d4C) and 2‘,3‘-Dideoxy-2‘,3‘-didehydro-β- l -5- fluorocytidine (β- l -Fd4C), Two Exceptionally Potent Inhibitors of Human Hepatitis B Virus (HBV) and Potent Inhibitors of Human Immunodeficiency Virus (HIV) in Vitro

✍ Scribed by Lin, Tai-Shun; Luo, Mei-Zhen; Liu, Mao-Chin; Zhu, Yong-Lian; Gullen, Elizabeth; Dutschman, Ginger E.; Cheng, Yung-Chi

Book ID
118221835
Publisher
American Chemical Society
Year
1996
Tongue
English
Weight
190 KB
Volume
39
Category
Article
ISSN
0022-2623

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ChemInform Abstract: Design and Synthesi
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2',3'-Dideoxy-B-L-cytidine (p-L-ddC), a potent inhibitor against human hepatitis B virus (HBV) and human immunodeficiency virus (HIV), has been stexwsjwifically synthesized from Garabinose in 9 steps. Recently, 2',3'dideoxy-~D-cytidiie (ddC) has been shown to be a potent inhibitor of the replication