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ChemInform Abstract: Design and Synthesis of 2′,3′-Dideoxy-2′,3′-didehydro-β-L- cytidine (β-L-d4C) and 2′,3′-Dideoxy-2′,3′-didehydro-β-L-5- fluorocytidine (β-L-Fd4C), Two Exceptionally Potent Inhibitors of Human Hepatitis B Virus (HBV) and Potent Inhibitors of Human Immunodeficiency Virus (HIV) in vitro.

✍ Scribed by T.-S. LIN; M.-Z. LUO; M.-C. LIU; Y.-L. ZHU; E. GULLEN; G. E. DUTSCHMAN; Y.-C. CHENG

Book ID
112036067
Publisher
John Wiley and Sons
Year
2010
Weight
37 KB
Volume
27
Category
Article
ISSN
0931-7597

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2',3'-Dideoxy-B-L-cytidine (p-L-ddC), a potent inhibitor against human hepatitis B virus (HBV) and human immunodeficiency virus (HIV), has been stexwsjwifically synthesized from Garabinose in 9 steps. Recently, 2',3'dideoxy-~D-cytidiie (ddC) has been shown to be a potent inhibitor of the replication