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Antiviral activity of 2′,3′-dideoxy-β-L-5-fluorocytidine (β-L-FddC) and 2′,3′-dideoxy-β-L-cytidine (β-L-ddC) against hepatitis B virus and human immunodeficiency virus type 1 in vitro

✍ Scribed by Lin Tai-Shun; Luo Mei-Zhen; Liu Mao-Chin; S.Balakrishna Pai; Ginger E. Dutschman; Cheng Yung-Chi


Book ID
115783750
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
470 KB
Volume
47
Category
Article
ISSN
0006-2952

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A stereospecific synthesis of 2′,3′-dide
✍ Tai-Shun Lin; Mei-Zhen Luo; Mao-Chin Liu 📂 Article 📅 1994 🏛 Elsevier Science 🌐 French ⚖ 258 KB

2',3'-Dideoxy-B-L-cytidine (p-L-ddC), a potent inhibitor against human hepatitis B virus (HBV) and human immunodeficiency virus (HIV), has been stexwsjwifically synthesized from Garabinose in 9 steps. Recently, 2',3'dideoxy-~D-cytidiie (ddC) has been shown to be a potent inhibitor of the replication