A stereospecific synthesis of 2′,3′-dideoxy-β-l-cytidine (β-l-ddC), a potent inhibitor against human hepatitis B virus (HBV) and human immunodeficiency virus (HIV)

✍ Scribed by Tai-Shun Lin; Mei-Zhen Luo; Mao-Chin Liu

• Publisher: Elsevier Science
• Year: 1994
• Tongue: French
• Weight: 258 KB
• Volume: 35
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)73214-x

✦ Synopsis

2',3'-Dideoxy-B-L-cytidine (p-L-ddC), a potent inhibitor against human hepatitis B virus (HBV) and human immunodeficiency virus (HIV), has been stexwsjwifically synthesized from Garabinose in 9 steps. Recently, 2',3'dideoxy-~D-cytidiie (ddC) has been shown to be a potent inhibitor of the replication of