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Deoxyadenosine-Based DNA Polymerase Photoprobes: Design, Synthesis, and Characterization as Inhibitors of the Escherichia coli DNA Polymerase I Klenow Fragment †,‡

✍ Scribed by Moore, Bob M.; Li, Ke; Doughty, Michael B.


Book ID
126047208
Publisher
American Chemical Society
Year
1996
Tongue
English
Weight
425 KB
Volume
35
Category
Article
ISSN
0006-2960

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A domain of the klenow fragment of Esche
✍ P. S. Freemont; Dr. D. L. Ollis; T. A. Steitz; C. M. Joyce 📂 Article 📅 1986 🏛 John Wiley and Sons 🌐 English ⚖ 868 KB

The Klenow fragment of DNA polymerase I from Escherichia coli has two enzymatic activities: DNA polymerase and 3'-5' exonuclease. The crystal structure showed that the fragment is folded into two distinct domains. The smaller domain has a binding site for deoxynucleoside monophosphate and a divalent