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Restoration of the DNA damage resistance of Deinococcus radiodurans DNA polymerase mutants by Escherichia coli DNA polymerase I and Klenow fragment

โœ Scribed by Gutman, Pabol D.; Fuchs, Pinhas; Minton, Kenneth W.


Book ID
120312369
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
993 KB
Volume
314
Category
Article
ISSN
0921-8777

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A domain of the klenow fragment of Esche
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The Klenow fragment of DNA polymerase I from Escherichia coli has two enzymatic activities: DNA polymerase and 3'-5' exonuclease. The crystal structure showed that the fragment is folded into two distinct domains. The smaller domain has a binding site for deoxynucleoside monophosphate and a divalent