Degradable polyethylenimine-alt-poly(ethylene glycol) copolymers as novel gene carriers
β Scribed by Mi Ran Park; Ki Ok Han; In Kwon Han; Myung Haing Cho; Jae Woon Nah; Yun Jaie Choi; Chong Su Cho
- Book ID
- 113690933
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 356 KB
- Volume
- 105
- Category
- Article
- ISSN
- 0168-3659
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## Abstract An ideal gene carrier is required both in safety and efficiency for transfection. Polyethylenimine (PEI), a wellβstudied cationic polymer, has been proved with high transfection efficiency, but is reported as toxicity in many cell lines. In this study, PEI was coupled with polyethylene
## Abstract Poly(ethylene glycol) (PEG) is widely used as a water soluble carrier for polymerβdrug conjugates. Herein, we report degradable linear PEG analogs (DPEGs) carrying multifunctional groups. The DPEGs were synthesized by a Michael addition based condensation polymerization of dithiols and