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Synthesis of Degradable Functional Poly(ethylene glycol) Analogs as Versatile Drug Delivery Carriers

✍ Scribed by Na Wang; Anjie Dong; Huadong Tang; Edward A. Van Kirk; Patrick A. Johnson; William J. Murdoch; Maciej Radosz; Youqing Shen

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
293 KB
Volume
7
Category
Article
ISSN
1616-5187

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✦ Synopsis

Abstract

Poly(ethylene glycol) (PEG) is widely used as a water soluble carrier for polymer‐drug conjugates. Herein, we report degradable linear PEG analogs (DPEGs) carrying multifunctional groups. The DPEGs were synthesized by a Michael addition based condensation polymerization of dithiols and PEG diacrylates (PEGDA) or dimethacrylates (PEGDMA). They were stable at pH 7.4 but quickly degraded at pH 6.0 and 5.0. Thus, DPEGs could be used as drug carriers without concern for their retention in the body. DPEGs could be made to carry such functional groups as terminal thiol or (meth)acrylate and pendant hydroxyl groups. The functional groups were used for conjugation of drugs and targeting groups. This new type of PEG analog will be useful for drug delivery and the PEGylation of biomolecules and colloidal particles.

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