## Abstract ## Background Polyethylenimine (PEI) vectors are widely used in gene delivery because of their high transfection efficiency owing to a unique proton sponge effect. An increase in molecular weight increases transfection efficiency, but simultaneously results in increased toxicity. There
Degradable poly(ester amine) based on poly(ethylene glycol) dimethacrylate and polyethylenimine as a gene carrier
β Scribed by Jia-Hui Yu; Jin Huang; Jae-Woon Nah; Myung-Haing Cho; Chong-Su Cho
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 388 KB
- Volume
- 115
- Category
- Article
- ISSN
- 0021-8995
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## Abstract ## Background Polyethylenimine (PEI) is toxic although it is one of the most successful and widely used gene delivery polymers with the aid of the proton sponge effect. Therefore, development of new novel gene delivery carriers having high efficiency with less toxicity is necessary. #
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