Degeneration of cholecystokinin-immunoreactive afferents to the VPL thalamus in a mouse model of Niemann-Pick disease type C
β Scribed by Shinji Ohara; Yoko Ukita; Haruaki Ninomiya; Kousaku Ohno
- Book ID
- 113499919
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 210 KB
- Volume
- 1022
- Category
- Article
- ISSN
- 0006-8993
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## Abstract NiemannβPick disease type C (NPC) is a progressive neurodegenerative disorder characterized by accumulation of free cholesterol in lysosomes, mainly due to a mutation in the NPC1 gene. The pathophysiological basis of the neural disorders in NPC, however, is not well understood. We found
## Abstract NiemannβPick disease type C (NPC) is a deadly neurodegenerative disease often caused by mutation in a gene called NPC1, which results in the accumulation of unesterified cholesterol and glycosphingolipids in the endosomalβlysosomal system. Most studies on the mechanisms of neurodegenera