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Defective S Phase Chromatin Assembly Causes DNA Damage, Activation of the S Phase Checkpoint, and S Phase Arrest

โœ Scribed by Xiaofen Ye; Alexa A Franco; Hidelita Santos; David M Nelson; Paul D Kaufman; Peter D Adams


Book ID
117737031
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
534 KB
Volume
11
Category
Article
ISSN
1097-2765

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## Abstract We have studied the rate of DNA synthesis, cell cycle distribution, formation of ฮณโ€H2AX, and Rad51 nuclear foci and association of Rad51 with the nuclear matrix after treatment of HeLa cells with the interstrand crosslinking agent mitomycin C (MMC) in the presence of the kinase inhibito