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ERK activity facilitates activation of the S-phase DNA damage checkpoint by modulating ATR function

โœ Scribed by Wu, D; Chen, B; Parihar, K; He, L; Fan, C; Zhang, J; Liu, L; Gillis, A; Bruce, A; Kapoor, A


Book ID
110070181
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
499 KB
Volume
25
Category
Article
ISSN
0950-9232

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## Abstract We have studied the rate of DNA synthesis, cell cycle distribution, formation of ฮณโ€H2AX, and Rad51 nuclear foci and association of Rad51 with the nuclear matrix after treatment of HeLa cells with the interstrand crosslinking agent mitomycin C (MMC) in the presence of the kinase inhibito