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Mammalian G1- and S-phase checkpoints in response to DNA damage

โœ Scribed by Jiri Bartek; Jiri Lukas

Book ID
114309317
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
149 KB
Volume
13
Category
Article
ISSN
0955-0674

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The inability to repair DNA damage properly in mammals leads to various disorders and enhanced rates of tumour development. Organisms respond to chromosomal insults by activating a complex damage response pathway. This pathway regulates known responses such as cell-cycle arrest and apoptosis (progra