𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The DNA damage response: putting checkpoints in perspective

✍ Scribed by Elledge, Stephen J.; Zhou, Bin-Bing S.

Book ID
109771631
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
179 KB
Volume
408
Category
Article
ISSN
0028-0836

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✦ Synopsis

The inability to repair DNA damage properly in mammals leads to various disorders and enhanced rates of tumour development. Organisms respond to chromosomal insults by activating a complex damage response pathway. This pathway regulates known responses such as cell-cycle arrest and apoptosis (programmed cell death), and has recently been shown to control additional processes including direct activation of DNA repair networks.

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✍ Bryn A. Bridges πŸ“‚ Article πŸ“… 1995 πŸ› John Wiley and Sons 🌐 English βš– 827 KB

## Abstract The concept of regulatory β€˜checkpoints’ in the eukaryotic cycle has proved to be a fruitful one. Here, its applicability to the bacterial cell cycle is examined. A primitive DNA damage checkpoint operates in __E. coli__ such that, after exposure to ultraviolet light, while excision repa