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Checkpoint-dependent phosphorylation of Exo1 modulates the DNA damage response

✍ Scribed by Morin, Isabelle; Ngo, Hien-Ping; Greenall, Amanda; Zubko, Mikhajlo K; Morrice, Nick; Lydall, David

Book ID: 109849579
Publisher: Nature Publishing Group
Year: 2008
Tongue: English
Weight: 814 KB
Volume: 27
Category: Article
ISSN: 0261-4189
DOI: 10.1038/emboj.2008.171

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## Abstract The tumor suppressor p53 plays a central role in the DNA damage response. After exposure to genotoxic stress, p53 can both positively and negatively regulate cell fate. Initially, p53 promotes cell survival by inducing cell cycle arrest, DNA repair, and other pro‐survival pathways. Howe