Chk2-dependent phosphorylation of XRCC1 in the DNA damage response promotes base excision repair
β Scribed by Chou, Wen-Cheng; Wang, Hui-Chun; Wong, Fen-Hwa; Ding, Shian-ling; Wu, Pei-Ei; Shieh, Sheau-Yann; Shen, Chen-Yang
- Book ID
- 109849609
- Publisher
- Nature Publishing Group
- Year
- 2008
- Tongue
- English
- Weight
- 645 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0261-4189
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract ## BACKGROUND. Tobacco smoke contains numerous carcinogens that cause DNA damage, including oxidative lesions that are removed effectively by the baseβexcision repair (BER) pathway, in which adenosine diphosphate ribosyl transferase (ADPRT), xβray repair crossβcomplementing 1 (XRCC1),
The OGG1 gene of Saccharomyces cerevisiae encodes a DNA glycosylase that excises 7,8-dihydro-8-oxoguanine (8-OxoG). When compared to wild-type, ogg1 mutants show an increase in the frequency of GC to TA transversions, indicating a role for Ogg1 in the repair of 8-OxoG. Here we report an increased fr