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Synergism between base excision repair, mediated by the DNA glycosylases Ntg1 and Ntg2, and nucleotide excision repair in the removal of oxidatively damaged DNA bases in Saccharomyces cerevisiae

✍ Scribed by L. Gellon; R. Barbey; P. Auffret van der Kemp; D. Thomas; S. Boiteux

Publisher
Springer
Year
2001
Tongue
English
Weight
282 KB
Volume
265
Category
Article
ISSN
1617-4615

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The OGG1 gene of Saccharomyces cerevisiae encodes a DNA glycosylase that excises 7,8-dihydro-8-oxoguanine (8-OxoG). When compared to wild-type, ogg1 mutants show an increase in the frequency of GC to TA transversions, indicating a role for Ogg1 in the repair of 8-OxoG. Here we report an increased fr