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A DNA damage checkpoint response in telomere-initiated senescence

โœ Scribed by Fagagna, Fabrizio d'Adda di; Reaper, Philip M.; Clay-Farrace, Lorena; Fiegler, Heike; Carr, Philippa; von Zglinicki, Thomas; Saretzki, Gabriele; Carter, Nigel P.; Jackson, Stephen P.

Book ID
109892504
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
515 KB
Volume
426
Category
Article
ISSN
0028-0836

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The inability to repair DNA damage properly in mammals leads to various disorders and enhanced rates of tumour development. Organisms respond to chromosomal insults by activating a complex damage response pathway. This pathway regulates known responses such as cell-cycle arrest and apoptosis (progra