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MDC1 is required for the intra-S-phase DNA damage checkpoint

✍ Scribed by Goldberg, Michal; Stucki, Manuel; Falck, Jacob; D'Amours, Damien; Rahman, Dinah; Pappin, Darryl; Bartek, Jiri; Jackson, Stephen P.


Book ID
109890911
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
467 KB
Volume
421
Category
Article
ISSN
0028-0836

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## Abstract We have studied the rate of DNA synthesis, cell cycle distribution, formation of γ‐H2AX, and Rad51 nuclear foci and association of Rad51 with the nuclear matrix after treatment of HeLa cells with the interstrand crosslinking agent mitomycin C (MMC) in the presence of the kinase inhibito