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Cylindrol A: A novel inhibitor of Ras farnesyl-protein transferase from Cylindrocarpon lucidum

✍ Scribed by Sheo B. Singh; Deborah L. Zink; Gerald F. Bills; Rosalind G. Jenkins; Keith C. Silverman; Russell B. Lingham


Publisher
Elsevier Science
Year
1995
Tongue
French
Weight
217 KB
Volume
36
Category
Article
ISSN
0040-4039

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✍ Peter E. Maligres; Marjorie S. Waters; Steven A. Weissman; J. Christopher McWill πŸ“‚ Article πŸ“… 2003 πŸ› Journal of Heterocyclic Chemistry 🌐 English βš– 128 KB

## Abstract The synthesis of __ras__ farnesyl‐protein transferase inhibitor **1** is described on a multi‐kilogram scale. Retrosynthetic analysis reveals chloromethylimidazole **2** and a piperazinone **3** as viable precursors. The 1,5‐disubstituted imidazole system was regioselectively assembled