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Novel tricyclic aminoacetyl and sulfonamide inhibitors of Ras farnesyl protein transferase

โœ Scribed by F.George Njoroge; Bancha Vibulbhan; Carmen S. Alvarez; W.Robert Bishop; Joanne Petrin; Ronald J. Doll; V. Girijavallabhan; Ashit K. Ganguly


Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
275 KB
Volume
6
Category
Article
ISSN
0960-894X

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ChemInform Abstract: Novel Tricyclic Ami
โœ F. G. NJOROGE; B. VIBULBHAN; C. S. ALVAREZ; W. R. BISHOP; J. PETRIN; R. J. DOLL; ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 30 KB ๐Ÿ‘ 2 views

Novel Tricyclic Aminoacetyl and Sulfonamide Inhibitors of RAS Farnesyl Protein Transferase. -It is shown that derivatization of the amino group with a phthaloyl moiety increases inhibitory activity of the title compounds, cf. (IIIc) and (IIId). The potent inhibitors (III) and (V) are non-peptidic,