ChemInform Abstract: Novel Tricyclic Ami
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F. G. NJOROGE; B. VIBULBHAN; C. S. ALVAREZ; W. R. BISHOP; J. PETRIN; R. J. DOLL;
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Article
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2010
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John Wiley and Sons
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Novel Tricyclic Aminoacetyl and Sulfonamide Inhibitors of RAS Farnesyl Protein Transferase. -It is shown that derivatization of the amino group with a phthaloyl moiety increases inhibitory activity of the title compounds, cf. (IIIc) and (IIId). The potent inhibitors (III) and (V) are non-peptidic,