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Novel Triazole Based Inhibitors of Ras Farnesyl Transferase.

โœ Scribed by Ashis K. Saha; Li Liu; Richard Simoneaux; Bart DeCorte; Christophe Meyer; Stacy Skrzat; Henry J. Breslin; Michael J. Kukla; Dave W. End


Publisher
John Wiley and Sons
Year
2006
Weight
16 KB
Volume
37
Category
Article
ISSN
0931-7597

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Novel Tricyclic Aminoacetyl and Sulfonamide Inhibitors of RAS Farnesyl Protein Transferase. -It is shown that derivatization of the amino group with a phthaloyl moiety increases inhibitory activity of the title compounds, cf. (IIIc) and (IIId). The potent inhibitors (III) and (V) are non-peptidic,