Preparation of a Clinically Investigated Ras Farnesyl Transferase Inhibitor.
โ Scribed by Peter E. Maligres; Marjorie S. Waters; Steven A. Weissman; J. Christopher McWilliams; Stephanie Lewis; Jennifer Cowen; Robert A. Reamer; R. P. Volante; Paul J. Reider; David Askin
- Publisher
- John Wiley and Sons
- Year
- 2003
- Weight
- 152 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0931-7597
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๐ SIMILAR VOLUMES
Novel Tricyclic Aminoacetyl and Sulfonamide Inhibitors of RAS Farnesyl Protein Transferase. -It is shown that derivatization of the amino group with a phthaloyl moiety increases inhibitory activity of the title compounds, cf. (IIIc) and (IIId). The potent inhibitors (III) and (V) are non-peptidic,
Stereospecific Synthesis of a Novel Farnesyl Protein Transferase Inhibitor, Valinoctin A and Its Analogues. -The valinoctin A analogue (VIII), prepared via Curtius rearrangement of an intermediate azide, shows essentially the same inhibitory activity as the parent compound. -