✦ LIBER ✦

Synthesis of chaetomellic acid A: A potent inhibitor of Ras farnesyl-protein transferase

✍ Scribed by Sheo B. Singh

Publisher: Elsevier Science
Year: 1993
Tongue: French
Weight: 248 KB
Volume: 34
Category: Article
ISSN: 0040-4039
DOI: 10.1016/0040-4039(93)88094-y

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

A cobaloxime-mediated synthesis of the r

A cobaloxime-mediated synthesis of the ras farnesyl-protein transferase inhibitor chaetomellic acid A

✍ Bruce P. Branchaud; Rachel M. Slade 📂 Article 📅 1994 🏛 Elsevier Science 🌐 French ⚖ 159 KB

A Simple and Efficient Route to Chaetome

A Simple and Efficient Route to Chaetomellic Anhydride A: A Potent Natural Ras Farnesyl-Protein Transferase Inhibitor.

✍ Laurent De Buyck; Rita Cagnoli; Franco Ghelfi; Giulia Merighi; Adele Mucci; Ugo 📂 Article 📅 2004 🏛 John Wiley and Sons ⚖ 8 KB 👁 2 views

Isolation and structure of chaetomellic

Isolation and structure of chaetomellic acids A and B from Chaetomella acutiseta: farnesyl pyrophosphate mimic inhibitors of ras farnesyl-protein transferase

✍ Sheo B. Singh; Deborah L. Zink; Jerrold M. Liesch; Michael A. Goetz; Rosalind G. 📂 Article 📅 1993 🏛 Elsevier Science 🌐 French ⚖ 702 KB

## Famesyl-Protein transfuase catalyses a post-translational mociificadon of Ras that is obligatory for the cell trarqtorming activity of this oncogene protebt. The screening of natural products to iden@fy inhibitors of this enzyme as a potential anticancer agents. has led to the isolation #two nove

ChemInform Abstract: Synthesis of Chaeto

ChemInform Abstract: Synthesis of Chaetomellic Anhydride A, a Potent Inhibitor of RAS Protein Farnesyltransferase.

✍ Takehiko Yoshimitsu; Yoshimasa Arano; Tomohiro Kaji; Tatsunori Ino; Hiroto Nagao 📂 Article 📅 2009 🏛 John Wiley and Sons ⚖ 23 KB 👁 2 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v

Preparation of a Clinically Investigated

Preparation of a Clinically Investigated Ras Farnesyl Transferase Inhibitor.

✍ Peter E. Maligres; Marjorie S. Waters; Steven A. Weissman; J. Christopher McWill 📂 Article 📅 2003 🏛 John Wiley and Sons ⚖ 152 KB 👁 2 views

Preparation of a clinically investigated

Preparation of a clinically investigated ras farnesyl transferase inhibitor

✍ Peter E. Maligres; Marjorie S. Waters; Steven A. Weissman; J. Christopher McWill 📂 Article 📅 2003 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 128 KB

## Abstract The synthesis of __ras__ farnesyl‐protein transferase inhibitor **1** is described on a multi‐kilogram scale. Retrosynthetic analysis reveals chloromethylimidazole **2** and a piperazinone **3** as viable precursors. The 1,5‐disubstituted imidazole system was regioselectively assembled