A cobaloxime-mediated synthesis of the ras farnesyl-protein transferase inhibitor chaetomellic acid A
β Scribed by Bruce P. Branchaud; Rachel M. Slade
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- French
- Weight
- 159 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0040-4039
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## Famesyl-Protein transfuase catalyses a post-translational mociificadon of Ras that is obligatory for the cell trarqtorming activity of this oncogene protebt. The screening of natural products to iden@fy inhibitors of this enzyme as a potential anticancer agents. has led to the isolation #two nove
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