AbMract: A new protocol for the synthesis of [l, 2-a]-fused benzimidazoles and imidazoles has been developed using intramolecular homolytic aromatic substitution via a)-alkyl radicals generated from 1-(oJbenzeneselenylalkyl)-2-(benzenesulfenyl)-benzimidazoles and -2-(p-toluenesulfonyl)imidazoles.
Cyclisation of carbinyl radicals onto imines and hydrazones
โ Scribed by W.Russell Bowman; Peter T. Stephenson; Nicholas K. Terrett; Adrian R. Young
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- French
- Weight
- 325 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0040-4039
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๐ SIMILAR VOLUMES
Thiophenol radical induced cyclisation of N-dimethyltriazolyl imines is reported. Ethylenic but also acetylenic tethered hydrazones are cyclisud to cycloalkyl hydrazine under smooth conditions. A comparative study with oxime ethers is described.
A novel synthetic protocol for the synthesis of [1,2-b]-fused bicyclic pyrazoles has been developed using radical cyclisation. The protocol uses cyclisation of pyrazole-1-(v-alkyl) radicals generated from 1-[v-(phenylselenyl)alkyl]-pyrazole precursors. The pyrazole natural product, withasomnine (3-p
Radical cyclizations have attracted considerable interest in recent years, both synthetically' and mechanistically.' Although radical cyclizations of alkyl radicals onto C=C and GO bonds' have been studied extensively, radical cyclizations to C=N bonds received relatively much less attention. Radica