Radical Cyclization onto Imidazoles and Benzimidazoles. -A new facile route to imidazoles and benzimidazoles is developed. Radical reaction of the benzimidazole (V) indicates that the presence of a leaving group at the C-2 position is essential for successful cyclization. -(ALDABBAGH,
Radical cyclisation onto imidazoles and benzimidazoles
โ Scribed by Fawaz Aldabbagh; W.Russell Bowman
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- French
- Weight
- 128 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0040-4039
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โฆ Synopsis
AbMract: A new protocol for the synthesis of [l, 2-a]-fused benzimidazoles and imidazoles has been developed using intramolecular homolytic aromatic substitution via a)-alkyl radicals generated from 1-(oJbenzeneselenylalkyl)-2-(benzenesulfenyl)-benzimidazoles and -2-(p-toluenesulfonyl)imidazoles.
๐ SIMILAR VOLUMES
Radical Cyclization onto Imidazoles and Benzimidazoles. -A new method to prepare fused imidazoles like (II) and benzimidazoles such as (IV) is reported. -(ALDABBAGH, F.;
Iminyl radicals, generated by 5-exo cyclisation of alkyl, vinyl and aryl C-centred radicals onto nitriles, undergo b-scission (nitrile translocation), reduction or tandem cyclisation onto alkenes depending on the nature of the a-substituent. 5-exo Cyclisations of aryl radicals onto nitriles undergo