Synthesis of nitrogen heterocycles using tandem radical cyclisation of imines
โ Scribed by W.Russell Bowman; Peter T. Stephenson; Adrian R. Young
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- French
- Weight
- 261 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0040-4039
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๐ SIMILAR VOLUMES
## Abstract For Abstract see ChemInform Abstract in Full Text.
A generalised radical reaction has been used to synthesise heterocyclic compounds which could serve as ligands for drug discovery. Attempt also have been made to rationalise the formation of oxidation products formed during TBTH reaction.
The use of radical cyclisations allows direct access to a family of azaspiroeyclic ketones, including compounds having the azaspiro[4,4]nonane, and azaspiro[5S]undecane structures which are found in the alkaloids cephalotaxine and histrionicotoxin.