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Cyclin D1 gene (CCND1) mutations in endometrial cancer

✍ Scribed by Moreno-Bueno, Gema; Rodríguez-Perales, Sandra; Sánchez-Estévez, Carolina; Hardisson, David; Sarrió, David; Prat, Jaime; Cigudosa, Juan C; Matias-Guiu, Xavier; Palacios, José

Book ID
110067954
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
196 KB
Volume
22
Category
Article
ISSN
0950-9232

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## Abstract Cyclin D1 regulates G1 cell cycle progression by controlling the phosphorylation of the retinoblastoma protein. This pathway is frequently deregulated in many malignancies. In neuroblastoma, however, no consistent G1 cell cycle checkpoint aberrations have been found. We examined the pos