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Amplification and Expression of Cyclin D Genes (CCND1 CCND2 and CCND3) in Human Malignant Gliomas

✍ Scribed by Rainer Büschges; Ruthild G. Weber; Bertrand Actor; Peter Lichter; V. Peter Collins; Guido Reifenberger

Book ID
111403945
Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
145 KB
Volume
9
Category
Article
ISSN
1015-6305

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## Abstract Cyclin D1 regulates G1 cell cycle progression by controlling the phosphorylation of the retinoblastoma protein. This pathway is frequently deregulated in many malignancies. In neuroblastoma, however, no consistent G1 cell cycle checkpoint aberrations have been found. We examined the pos