✦ LIBER ✦

Heterogeneity of the proliferative fraction and cyclin D1/CCND1 gene amplification in head and neck squamous cell carcinoma

✍ Scribed by Adel K. El-Naggar; Kim Steck; John G. Batsakis

Publisher: John Wiley and Sons
Year: 1995
Tongue: English
Weight: 537 KB
Volume: 21
Category: Article
ISSN: 0196-4763
DOI: 10.1002/cyto.990210110

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

PRAD-1 (CCND1)/Cyclin D1 oncogene amplif

PRAD-1 (CCND1)/Cyclin D1 oncogene amplification in primary head and neck squamous cell carcinoma

✍ Troy Callender; Adel K. El-Naggar; Ming S. Lee; Robert Frankenthaler; Mario A. L 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 657 KB

## Background. Abnormalities in chromosome llq13 regions have been frequently found in head and neck squamous carcinoma. Recent studies indicate that the PRAD-1 (also CCNDI), which encodes cyclin D1, is a putative oncogene that is an important component of this region. Methods. DNA was extracted

TP53 gene mutations and CCND1 gene ampli

TP53 gene mutations and CCND1 gene amplification in head and neck squamous cell carcinoma cell lines

✍ Li Xu; Bruce J. Davidson; V. V. V. S. Murty; Rong-Guo Li; Peter G. Sacks; Pilar 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 French ⚖ 711 KB

Amplification of cyclin D1 in squamous c

Amplification of cyclin D1 in squamous cell carcinoma of the head and neck and the prognostic value of chromosomal abnormalities and cyclin D1 overexpression

✍ Jan A. Åkervall; Rob J. A. M. Michalides; Hiroyuki Mineta; Alfons Balm; Åke Borg 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 208 KB 👁 2 views

## Background: Abnormalities of chromosome band 11q13 are frequent in squamous cell carcinoma of the head and neck (scchn). the oncogene ccnd1 is located at 11q13 and encodes cyclin d1, a cell cycle-regulating protein. the authors investigated the clinical relevance and associations between amplifi

Cyclin-D1-gene amplification is a more p

Cyclin-D1-gene amplification is a more potent prognostic factor than its protein over-expression in human head-and-neck squamous-cell carcinoma

✍ Ryoichi Kyomoto; Hirobumi Kumazawa; Yoshinobu Toda; Noriko Sakaida; Akiharu Okam 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 French ⚖ 332 KB 👁 2 views

To evaluate the prognostic significance of cyclin D1 protein/gene expressions in human head-and-neck squamous-cell carcinoma (HNSCC), we examined amplification of the cyclin-D1 gene (CCND1) by the differential PCR method and over-expression of cyclin-D1 protein by immunohistochemistry in 45 paraffin

Analysis of gene amplification in head-a

Analysis of gene amplification in head-and-neck squamous-cell carcinomas

✍ J. Helen Leonard; John H. Kearsley; Georgia Chenevix-Trench; Nicholas K. Hayward 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 French ⚖ 656 KB

The presence of gene amplification was determined in 66 fresh head-and-neck SCC specimens using a battery of 9 different probes. Amplification of at least one gene was found in I 2 samples (18%), of which 7 were amplified at multiple loci (58%). We observed amplifications for EGFR (10% of samples) a

Human papillomavirus infection and cycli

Human papillomavirus infection and cyclin D1 gene amplification in laryngeal squamous cell carcinoma: Biologic function and clinical significance

✍ Giovanni Almadori; Jacopo Galli; Gabriella Cadoni; Francesco Bussu; Maurizio Mau 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 197 KB 👁 1 views

## Background: Human papillomavirus (hpv) infection is suspected to be a risk factor for head and neck, and in particular for laryngeal, carcinogenesis. cyclin d1 gene (ccnd1) overexpression and amplification have been shown to play a role as prognostic factors in many human cancers, among which ar