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Analysis of gene amplification in head-and-neck squamous-cell carcinomas

✍ Scribed by J. Helen Leonard; John H. Kearsley; Georgia Chenevix-Trench; Nicholas K. Hayward

Publisher
John Wiley and Sons
Year
1991
Tongue
French
Weight
656 KB
Volume
48
Category
Article
ISSN
0020-7136

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✦ Synopsis

The presence of gene amplification was determined in 66 fresh head-and-neck SCC specimens using a battery of 9 different probes. Amplification of at least one gene was found in I 2 samples (18%), of which 7 were amplified at multiple loci (58%). We observed amplifications for EGFR (10% of samples) and c-myc (9%), as well as co-amplification of bcl-llint-2 (7%).

No amplifications were demonstrated for c-Ha-ras-l , TGFar, c-mos, c-erbl-2, or c-erbA-2. The incidence of proto-oncogene amplification in head-and-neck SCC patients is comparable to that reported for other solid tumours. There was no statistically significant difference in survival between patients with or without gene amplification. However, the presence of multiple amplifications in several patients with advanced primary tumours suggests that the accumulation of genetic changes may correlate more closely with tumour size than with inherent biologic aggression.

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