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TP53 gene mutations and CCND1 gene amplification in head and neck squamous cell carcinoma cell lines

✍ Scribed by Li Xu; Bruce J. Davidson; V. V. V. S. Murty; Rong-Guo Li; Peter G. Sacks; Pilar Garin-Chesa; Stimson P. Schantz; R. S. K. Chaganti

Publisher
John Wiley and Sons
Year
1994
Tongue
French
Weight
711 KB
Volume
59
Category
Article
ISSN
0020-7136

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## Background. Abnormalities in chromosome llq13 regions have been frequently found in head and neck squamous carcinoma. Recent studies indicate that the PRAD-1 (also CCNDI), which encodes cyclin D1, is a putative oncogene that is an important component of this region. Methods. DNA was extracted

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