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Convergent synthesis of the C31C46 domain of the phorboxazole natural products

✍ Scribed by Feryan Ahmed; Craig J Forsyth

Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
194 KB
Volume
39
Category
Article
ISSN
0040-4039

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✦ Synopsis

A convergent synthesis of the C31-C46 domain of the phorboxazole natural products has been developed. This involved the preparation of a C39-C46 dienyl iodide and a C31-C37 aldehyde, followed by their Cl('12-mediatcd coupling and final installation of the C46 (E)-vinyl bromide via an alkyne hydrostannation-bromination sequence.

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