𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthetic studies towards phorboxazole A. A convergent synthesis of the C31C46 polyene oxane-hemiacetal side chain

✍ Scribed by Gerald Pattenden; Alleyn T Plowright; James A Tornos; Tao Ye

Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
230 KB
Volume
39
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis

A convergent and stereoselective synthesis of the C31-C46 side chain unit in the marine natural product phorboxazole A, which accommodates five asymmetric centres, three carbon-to-carbon double bonds and an oxane-hemiacetal unit, is described.

📜 SIMILAR VOLUMES

Synthetic studies toward phorboxazole A.
Synthetic studies toward phorboxazole A. Stereoselective synthesis of the C3C19 and C20C32 subunits
✍ David R Williams; Michael P Clark; Martin A Berliner 📂 Article 📅 1999 🏛 Elsevier Science 🌐 French ⚖ 250 KB

A stereocontrolled synthesis of two fragments comprising the macrocyclic core of Phorboxazole A is described. The C3-C19 bis-pyran segment is prepared utilizing reiterative enantioselective allylations from homochiral aUylstannanes followed by stereoselective cyclizations. The pentasubstituted tetra