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The macrocyclic domain of phorboxazole A. A stereoselective synthesis of the C1C32 macrolactone

✍ Scribed by David R Williams; Michael P Clark

Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
192 KB
Volume
40
Category
Article
ISSN
0040-4039

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✦ Synopsis

A stereoselective synthesis of the C1~232 macrocyclic domain of phorboxazole A is described. Key steps have examined the convergent linkage of two major components for the formation of the CI9--C20 (E)-alkene, and the subsequent intramolecular (Z)olefination at C2-C 3 for ring closure of the macrocycle.

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