A convergent synthesis of the C31-C46 domain of the phorboxazole natural products has been developed. This involved the preparation of a C39-C46 dienyl iodide and a C31-C37 aldehyde, followed by their Cl('12-mediatcd coupling and final installation of the C46 (E)-vinyl bromide via an alkyne hydrosta
Synthesis of the central C18–C30 core of the phorboxazole natural products
✍ Scribed by Chi Sing Lee; Craig J. Forsyth
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- French
- Weight
- 165 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
Convergent Synthesis of the C31-C46 Domain of the Phorboxazole Natural Products. -The synthetic fragment (V) representing the C31-C46 domain of the phorboxazole natural products is prepared in 15 steps. Key-step is the CrCl 2 /NiCl 2 mediated coupling of the aldehyde (I) with the dienyl iodide (II)
A stereoselective synthesis of the C21 C27 fragment of phorboxazoles A and B was achieved in 12 linear steps via an intramolecular cyclization induced by mercury acetate, to afford a functionalized tetrahydropyran.
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