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Conformational Change Induced by ATP Binding in the Multidrug ATP-Binding Cassette Transporter BmrA †

✍ Scribed by Orelle, Cédric; Gubellini, Francesca; Durand, Anne; Marco, Sergio; Lévy, Daniel; Gros, Philippe; Di Pietro, Attilio; Jault, Jean-Michel


Book ID
127005258
Publisher
American Chemical Society
Year
2008
Tongue
English
Weight
388 KB
Volume
47
Category
Article
ISSN
0006-2960

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Resistance to multiple natural product drugs associated with reduced drug accumulation in human tumor cells may be conferred by either the 170 kDa P-glycoprotein or the 190 kDa multidrug resistance protein, MRP. Both MRP and P-glycoprotein belong to the large and ancient ATP-binding cassette (ABC) s