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Chemotherapy-induced resistance by ATP-binding cassette transporter genes

✍ Scribed by Jean-Pierre Gillet; Thomas Efferth; José Remacle

Book ID
113486655
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
831 KB
Volume
1775
Category
Article
ISSN
0304-419X

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Resistance to multiple natural product drugs associated with reduced drug accumulation in human tumor cells may be conferred by either the 170 kDa P-glycoprotein or the 190 kDa multidrug resistance protein, MRP. Both MRP and P-glycoprotein belong to the large and ancient ATP-binding cassette (ABC) s