Confirmation of LRRK2 S1647T variant as a risk factor for Parkinson’s disease in Southern China
✍ Scribed by Y. Zheng; Y. Liu; Q. Wu; H. Hong; H. Zhou; J. Chen; H. Wang; W. Xian; J. Li; Z. Liu; Z. Pei; L. Chen
- Book ID
- 111066487
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 96 KB
- Volume
- 18
- Category
- Article
- ISSN
- 1351-5101
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## Abstract Common genetic variants that increase the risk for Parkinson's disease may differentiate patient subgroups and influence future individualized therapeutic strategies. Herein we show evidence for __leucine‐rich repeat kinase 2 (LRRK2)__ c.4883G>C (R1628P) as a risk factor in ethnic Chine
## Abstract Mutations in __LRRK2__, the gene that encodes leucine‐rich repeat kinase 2 (LRRK2), are associated with autosomal dominant and sporadic forms of Parkinson's disease (PD) and are the most common genetic causes of PD. Recently, a R1628P variant has been reported as a risk factor for PD in