## Abstract Mutations in __LRRK2__, the gene that encodes leucine‐rich repeat kinase 2 (LRRK2), are associated with autosomal dominant and sporadic forms of Parkinson's disease (PD) and are the most common genetic causes of PD. Recently, a R1628P variant has been reported as a risk factor for PD in
The LRRK2 Arg1628Pro variant is a risk factor for Parkinson’s disease in the Chinese population
✍ Scribed by Chin-Song Lu; Yah-Huei Wu-Chou; Marina van Doeselaar; Erik J. Simons; Hsiu-Chen Chang; Guido J. Breedveld; Alessio Di Fonzo; Rou-Shayn Chen; Yi-Hsin Weng; Szu-Chia Lai; Ben A. Oostra; Vincenzo Bonifati
- Publisher
- Springer
- Year
- 2008
- Tongue
- English
- Weight
- 226 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1364-6745
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract We conducted a case–control study to determine the prevalence of the __LRRK2__ Gly2385Arg variant in patients with Parkinson's disease in Han population in mainland China. Heterozygous __LRRK2__ Gly2385Arg variant was identified in 14 of 235 patients with Parkinson's disease (5.69%), bu
## Abstract An association between mutations in the __glucocerebrosidase__ (__GBA__) gene and Parkinson's disease (PD) has been reported in several populations. We searched for four common __GBA__ mutations (L444P, F213I, R353W, and N370S) in 402 Chinese PD patients and 413 age‐ and sex‐matched con