LRRK2 R1628P variant is a risk factor of Parkinson's disease among Han-Chinese from mainland China

✍ Scribed by Zijuan Zhang; Jean-Marc Burgunder; Xingkai An; Yan Wu; Wenjun Chen; Jinhong Zhang; Yingcheng Wang; Yanming Xu; Yingru Gou; Guanggu Yuan; Xueye Mao; Rong Peng

• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 66 KB
• Volume: 24
• Category: Article
• ISSN: 0885-3185
• DOI: 10.1002/mds.22371

✦ Synopsis

Abstract

Mutations in LRRK2, the gene that encodes leucine‐rich repeat kinase 2 (LRRK2), are associated with autosomal dominant and sporadic forms of Parkinson's disease (PD) and are the most common genetic causes of PD. Recently, a R1628P variant has been reported as a risk factor for PD in Taiwan and Singapore. To determine the association of this variant and PD in the Han‐Chinese population from mainland China, we analyzed its frequency in a cohort of 600 patients and 459 unrelated healthy controls. Forty (6.7%) patients were heterozygous and 3 (0.5%) homozygous for the R1628P variant, which was significantly more frequent than in the controls [2.4% heterozygous and 0.0% homozygous, Odds ratio = 3.14, 95%CI: 1.60–6.17, P < 0.01]. Considering the age at onset, this difference was found only in late‐onset PD (older than 50) [Odds ratio = 3.76, 95% CI: 1.90–7.45, P < 0.01]. Our data confirms that the LRRK2 R1628P variant is associated with an increased risk to develop late onset PD in the ethnic Han‐Chinese population. © 2009 Movement Disorder Society