Analysis of Lrrk2 R1628P as a risk factor for Parkinson's disease

✍ Scribed by Owen A. Ross; Yih-Ru Wu; Mei-Ching Lee; Manabu Funayama; Meng-Ling Chen; Alexandra I. Soto; Ignacio F. Mata; Guey-Jen Lee-Chen; Chiung Mei Chen; Michelle Tang; Yi Zhao; Nobutaka Hattori; Matthew J. Farrer; Eng-King Tan; Ruey-Meei Wu

• Publisher: John Wiley and Sons
• Year: 2008
• Tongue: English
• Weight: 130 KB
• Volume: 64
• Category: Article
• ISSN: 0364-5134
• DOI: 10.1002/ana.21405

✦ Synopsis

Abstract

Common genetic variants that increase the risk for Parkinson's disease may differentiate patient subgroups and influence future individualized therapeutic strategies. Herein we show evidence for leucine‐rich repeat kinase 2 (LRRK2) c.4883G>C (R1628P) as a risk factor in ethnic Chinese populations. A study of 1,986 individuals from 3 independent centers in Taiwan and Singapore demonstrates that Lrrk2 R1628P increases risk for Parkinson's disease (odds ratio, 1.84; 95% confidence interval, 1.20–2.83; p = 0.006). Haplotype analysis suggests an ancestral founder for carriers approximately 2,500 years ago. These findings support the importance of LRRK2 variants in sporadic Parkinson's disease. Ann Neurol 2008