## Abstract The electrophoretic gelβbased chemical cleavage of the mismatch method gives an incomplete view of the DNA conformational changes induced by a single base mismatch. This spectroscopic study investigates the permanganate oxidation reactions with matched and mismatched DNA under constant
Comparative Study of Permanganate Oxidation Reactions of Nucleotide Bases by Spectroscopy
β Scribed by Chinh T Bui; Richard G.H Cotton
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 46 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0045-2068
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β¦ Synopsis
The permanganate oxidation of free nucleotide bases was successfully studied in aqueous solution of tetraethylammonium chloride using spectroscopic techniques. The reaction was highly selective toward thymine and uracil, less with cytosine, very little reaction on guanine, and no reaction on adenine. α§ 2002 Elsevier Science (USA)
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