𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Comparative pharmacokinetics of coumarin anticoagulants XXIX: Elimination kinetics and anticoagulant activity of (S)-(—)-warfarin in rats before and after chronic administration

✍ Scribed by Avraham Yacobi; Gerhard Levy

Publisher
John Wiley and Sons
Year
1977
Tongue
English
Weight
388 KB
Volume
66
Category
Article
ISSN
0022-3549

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Comparative pharmacokinetics of coumarin
Comparative pharmacokinetics of coumarin anticoagulants XIV: Relationship between protein binding, distribution, and elimination kinetics of warfarin in rats
✍ Avraham Yacobi; Gerhard Levy 📂 Article 📅 1975 🏛 John Wiley and Sons 🌐 English ⚖ 466 KB

d e n quantitation of small sulfamethazine peaks impractical. The chloroform wash of the basic aqueous mixture seems to affect this component m a t . Overwashing at this point, however, causes a loss of sulfamethazine. Homogenizing or grinding the tissue prior to extraction tends to improve recover

Comparative pharmacokinetics of coumarin
Comparative pharmacokinetics of coumarin anticoagulants L: Physiologic modeling of S-warfarin in rats and pharmacologic target-mediated warfarin disposition in man
✍ Gerhard Levy; Donald E. Mager; Wing K. Cheung; William J. Jusko 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 142 KB

The anticoagulant warfarin exemplifies a type of drug that exhibits high affinity to pharmacologic target sites of limited capacity, resulting in unusual concentration-dependent distribution and elimination properties. The time course of warfarin concentrations in the serum, liver, kidneys, muscle,