𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Comparative pharmacokinetics of coumarin anticoagulants XLVI: Effect of treatment with phenobarbital on pharmacokinetics of (S)-(−)-warfarin in rats

✍ Scribed by Avraham Yacobi; John T. Slattery; Gerhard Levy


Publisher
John Wiley and Sons
Year
1980
Tongue
English
Weight
358 KB
Volume
69
Category
Article
ISSN
0022-3549

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Comparative pharmacokinetics of coumarin
✍ Kanji Takada; Gerhard Levy 📂 Article 📅 1979 🏛 John Wiley and Sons 🌐 English ⚖ 385 KB

The purpose of this study was to determine if hepatic warfarin uptake, which has a major quantitative effect on warfarin distribution in rats, is concentration dependent. Adult male rats received either 0.1 or 1.0 mg of racemic warfarin/kg iv and were killed 6 hr later. With increasing dose, the con

Comparative pharmacokinetics of coumarin
✍ Gerhard Levy; Donald E. Mager; Wing K. Cheung; William J. Jusko 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 142 KB

The anticoagulant warfarin exemplifies a type of drug that exhibits high affinity to pharmacologic target sites of limited capacity, resulting in unusual concentration-dependent distribution and elimination properties. The time course of warfarin concentrations in the serum, liver, kidneys, muscle,