Comparative pharmacokinetics of coumarin anticoagulants XLVI: Effect of treatment with phenobarbital on pharmacokinetics of (S)-(−)-warfarin in rats
✍ Scribed by Avraham Yacobi; John T. Slattery; Gerhard Levy
- Publisher
- John Wiley and Sons
- Year
- 1980
- Tongue
- English
- Weight
- 358 KB
- Volume
- 69
- Category
- Article
- ISSN
- 0022-3549
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The purpose of this study was to determine if hepatic warfarin uptake, which has a major quantitative effect on warfarin distribution in rats, is concentration dependent. Adult male rats received either 0.1 or 1.0 mg of racemic warfarin/kg iv and were killed 6 hr later. With increasing dose, the con
The anticoagulant warfarin exemplifies a type of drug that exhibits high affinity to pharmacologic target sites of limited capacity, resulting in unusual concentration-dependent distribution and elimination properties. The time course of warfarin concentrations in the serum, liver, kidneys, muscle,