Comparative pharmacokinetics of coumarin anticoagulants XV: Relationship between pharmacokinetics of dicumarol and warfarin in rats
โ Scribed by Avraham Yacobi; Chii-Ming Lai; Gerhard Levy
- Publisher
- John Wiley and Sons
- Year
- 1975
- Tongue
- English
- Weight
- 384 KB
- Volume
- 64
- Category
- Article
- ISSN
- 0022-3549
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๐ SIMILAR VOLUMES
d e n quantitation of small sulfamethazine peaks impractical. The chloroform wash of the basic aqueous mixture seems to affect this component m a t . Overwashing at this point, however, causes a loss of sulfamethazine. Homogenizing or grinding the tissue prior to extraction tends to improve recover
The purpose of this study was to determine if hepatic warfarin uptake, which has a major quantitative effect on warfarin distribution in rats, is concentration dependent. Adult male rats received either 0.1 or 1.0 mg of racemic warfarin/kg iv and were killed 6 hr later. With increasing dose, the con