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Comparative pharmacokinetics of coumarin anticoagulants XXXIII: Frequency distribution of dicumarol total clearance in rats

โœ Scribed by Chii-Ming Lai; Gerhard Levy


Publisher
John Wiley and Sons
Year
1978
Tongue
English
Weight
500 KB
Volume
67
Category
Article
ISSN
0022-3549

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๐Ÿ“œ SIMILAR VOLUMES


Comparative pharmacokinetics of coumarin
โœ Kanji Takada; Gerhard Levy ๐Ÿ“‚ Article ๐Ÿ“… 1979 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 385 KB

The purpose of this study was to determine if hepatic warfarin uptake, which has a major quantitative effect on warfarin distribution in rats, is concentration dependent. Adult male rats received either 0.1 or 1.0 mg of racemic warfarin/kg iv and were killed 6 hr later. With increasing dose, the con