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Comparative pharmacokinetics of coumarin anticoagulants II. Pharmacokinetics of bishydroxycoumarin elimination in the rat, guinea pig, dog, and rhesus monkey

✍ Scribed by Renpei Nagashima; Gerhard Levy; Nathan Back

Publisher: John Wiley and Sons
Year: 1968
Tongue: English
Weight: 356 KB
Volume: 57
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.2600570113

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d e n quantitation of small sulfamethazine peaks impractical. The chloroform wash of the basic aqueous mixture seems to affect this component m a t . Overwashing at this point, however, causes a loss of sulfamethazine. Homogenizing or grinding the tissue prior to extraction tends to improve recover