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Combinatorial Synthesis of Heterocycles: Solid-Phase Synthesis of 2-Amino-4(1 H )-quinazolinone Derivatives

✍ Scribed by Gopalsamy, Ariamala; Yang, Hui


Book ID
121472421
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
53 KB
Volume
2
Category
Article
ISSN
1520-4766

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Solid-phase combinatorial synthesis of 4
✍ Mui Mui Sim; Cheng Leng Lee; A. Ganesan πŸ“‚ Article πŸ“… 1998 πŸ› Elsevier Science 🌐 French βš– 192 KB

Cyanoacetic acid was loaded on Wang resin and C-acylated using acid anhydrides and triethylamine as base. Resin cleavage with concomitant decarboxylation produces 13-keto nitriles. In the case of isatoic anhydrides, the resin-bound acylated intermediates undergo cyclative cleavage upon heating, lead